Affiliation:
1. Department of Otolaryngology Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510000 China
2. Department of Otolaryngology Longgang E.N.T. Hospital and Shenzhen Key Laboratory of E.N.T Institute of E.N.T. Shenzhen 518172 China
3. Department of Graduate and Scientific Research Zunyi Medical University Zhuhai Campus Zhuhai 519041 China
Abstract
AbstractAs one of the most common otologic diseases in the elderly, age‐related hearing loss (ARHL) usually characterized by hearing loss and cognitive disorders, which have a significant impact on the elderly's physical and mental health and quality of life. However, as a typical disease of aging, it is unclear why aging causes widespread hearing impairment in the elderly. As molecular biological experiments have been conducted for research recently, ARHL is gradually established at various levels with the application and development of integrated multi‐omics analysis in the studies of ARHL. Here, the recent progress in the application of multi‐omics analysis in the molecular mechanisms of ARHL development and therapeutic regimens, including the combined analysis of different omics, such as transcriptome, proteome, and metabolome, to screen for risk sites, risk genes, and differences in lipid metabolism, etc., is outlined and the integrated histological data further promote the profound understanding of the disease process as well as physiological mechanisms of ARHL. The advantages and disadvantages of multi‐omics analysis in disease research are also discussed and the authors speculate on the future prospects and applications of this part‐to‐whole approach, which may provide more comprehensive guidance for ARHL and aging disease prevention and treatment.
Funder
Shenzhen Science and Technology Innovation Program