OTX015 (MK-8628), a novel BET inhibitor, displaysin vitroandin vivoantitumor effects alone and in combination with conventional therapies in glioblastoma models

Author:

Berenguer-Daizé Caroline1,Astorgues-Xerri Lucile2,Odore Elodie23,Cayol Mylène1,Cvitkovic Esteban24,Noel Kay4,Bekradda Mohamed2,MacKenzie Sarah2,Rezai Keyvan3,Lokiec François3,Riveiro Maria E.2,Ouafik L'Houcine1

Affiliation:

1. Aix-Marseille Université, Inserm, CRO2 UMR_S 911; Marseille 13385 France

2. Oncology Therapeutic Development; 100 Rue Martre Clichy 92110 France

3. Department of Radio-Pharmacology; Institut Curie, René Huguenin Hospital; 35 Rue Daily Saint-Cloud 92210 France

4. Oncoethix SA (Now Oncoethix GmbH, a Wholly Owned Subsidiary of Merck Sharp and Dohme Corp.); Weystrasse 20 Lucerne 6000 Switzerland

Funder

SIRIC

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference35 articles.

1. Glioblastoma multiforme-an overview;Urbañska;Contemp Oncol (Pozn),2014

2. Pathology of gliomas and developments in molecular testing;Collins;Clin Oncol (R Coll Radiol),2014

3. Advances and challenges in the molecular biology and treatment of glioblastoma-Is there any hope for the future?;Veliz;Ann Transl Med,2015

4. Adult glioblastoma multiforme survival in the temozolomide era: A population-based analysis of surveillance, epidemiology, and end results registries;Darefsky;Cancer,2012

5. A randomized trial of bevacizumab for newly diagnosed glioblastoma;Gilbert;N Engl J Med,2014

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