Author:
Karson Craig N.,Bigelow Llewellyn B.,Kleinman Joel E.,Weinberger Daniel R.,Wyatt Richard Jed
Abstract
SummarySpontaneous eye blink rates, psychiatric symptoms and response to neuroleptic medication may all be mediated by dopamine. Fixed doses of haloperidol, a dopamine blocking agent, were administered for six weeks to 17 chronic schizophrenic patients who had been previously withdrawn from all medications. The change in blink rates caused by haloperidol corresponded to a change in the thought disturbance syndrome which measures positive symptoms (r =.48, P <.05). The relationship was particularly clear in patients with normal cerebral ventricles (r =.74, P <.01).
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Reference20 articles.
1. Premorbid adjustment and CT scan abnormalities in chronic schizophrenia;Weinberger;American Journal of Psychiatry,1980b
2. Cerebral Ventricular Enlargement in Chronic Schizophrenia
Cited by
30 articles.
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