Author:
Anisman Hymie,Zacharko Robert M.
Abstract
Stressors induce behavioural disturbances and neurochemical changes in animals, some of which are reminiscent of the symptoms and presumed neurochemical concomitants of depression in humans. Just as in humans, where considerable inter-individual variability is evident in the symptom profile of depression, there is marked inter-individual and inter-strain variability in the behavioural effects of stressors in animals. It is proposed that stressors induce adaptive neurochemical changes, failure of which may engender behavioural disturbances. Variability in the symptoms of depression and in the efficacy of its pharmacological treatment may reflect the biochemical heterogeneity of the illness. Inter-individual differences in vulnerability to stressor-provoked neurochemical changes may contribute to the behavioural profiles observed.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Reference81 articles.
1. Responding for brain stimulation: Stress and desmethylimipramine
2. Regulation of dopamine synthesis in the medial prefrontal cortex: studies in brain slices;Wolf;Journal of Pharmacology and Experimental Therapeutics,1986
3. Influence of the Mesocortical/Prefrontal Dopamine Neurons on Their Target Cells
Cited by
99 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献