Author:
Berrettini Wade H.,Nurnberger John I.,Hare Theodore,Gershon Elliott S.,Post Robert M.
Abstract
SummaryCSF and plasma GABA was measured in patients with bipolar affective illness and matched controls. There was no correlation between CSF and plasma GABA in 10 pairs of simultaneously obtained samples. Plasma GABA was significantly lower in a group of 10 euthymic medication-free bipolar patients compared to 41 normal volunteers (P <.02). This finding was replicated in a second study involving 6 patients and 10 normal volunteers. Twin studies showed a high correlation between members of 11 monozygotic twin pairs (P <.008). Diurnal variation was minimal, but bimonthly sampling over one year revealed somewhat higher values in the late summer compared to late winter.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
65 articles.
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