Evaluation of a 1 step TRAb Assay for the Detection of High-affinity Components to hTSHR: Evidences Indicating Superiority of the Assay in the Lower TRAb Range

Author:

ISHIHARA Takashi1,SAIKI Yasuhiko2,IKEKUBO Katsuji2,HINO Megumu2,IKEDA Kaori1,SON Cyeol1,IWAKURA Toshio1,KOBAYASHI Hiromasa1,MORI Toru3

Affiliation:

1. Department of Internal Medicine, Kobe City General Hospital

2. Department of Nuclear Medicine, Kobe City General Hospital

3. Department of Internal Medicine, Kyoto Higashiyama Takeda Hospital

Publisher

Japan Endocrine Society

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Reference34 articles.

1. 1. Smith BR, McLachlan SM, Furmaniak J (1988) Autoantibodies to the thyrotropin receptor. Endocr Rev 9: 106-121.

2. 2. Mori T, Akamizu T, Kosugi S, Sugawa H, Inoue D, Okuda J, Ueda Y (1994) Recent progress in TSH receptor studies with a new concept of autoimmune TSH receptor disease. Endocr J 41: 1-11.

3. 3. Kohn LD, Shimura H, Shimura Y, Hidaka A, Giuliani C, Napolitano G, Ohmori M, Laglia G, Saji M (1995) The thyrotropin receptor. Vitam Horm 50: 287-384.

4. 4. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM (1998) The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 19: 673-716.

5. 5. Costagliola S, Morgenthaler NG, Hoermann R, Badenhoop K, Struck K, Freitag D, Poertl S, Weglohner W, Hollidt JM, Quadbeck B, Dumont JE, Schumm-Draeger PM, Bergmann A, Mann K, Vassart G, Usadel KH (1999) Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease. J Clin Endocrinol Metab 84: 90-97.

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