First-degree Atrioventricular Block in Alprazolam Overdose Reversed by Flumazenil-Reference-Cited by-同舟云学术

First-degree Atrioventricular Block in Alprazolam Overdose Reversed by Flumazenil

Published:1999-03 Issue:3 Volume:51 Page:367-370
ISSN:0022-3573
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Mullins Michael E¹

Affiliation:

1. Oregon Poison Center, Department of Emergency Medicine, Oregon Health Sciences University, Portland, Oregon, USA

Abstract

Abstract This report describes a case of alprazolam overdose associated with marked first-degree atrioventricular block reversed by flumazenil. Animal and human evidence suggests activity of certain benzodiazepines at peripheral benzodiazepine receptors in the myocardium and elsewhere. Myocardial benzodiazepine receptor ligands appear to affect calcium-channel activity, which may explain the clinical findings. Benzodiazepines may behave like weak calcium-channel blockers. This case raises the possibility of a potential role for flumazenil as an adjunct in the management of calcium-channel blocker toxicity.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/51/3/367/36785183/0022357991772385.pdf

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