INNOVATIVE APPROACHES TO PHARMACOTHERAPY OF SYSTEMIC AUTOIMMUNE DISEASES IN THE CONDITIONS OF THE COVID-19 PANDEMIC

Abstract

Introduction. In the current context of the spread of the coronavirus pandemic, the role of pharmacotherapy in the maintenance of immunopathological syndromes among patients with systemic diseases and patients with dual health disorders is growing. The need to adjust the pharmacotherapy regimens of systemic autoimmune diseases arises when addressing issues of quality, economic and physical availability of drugs in accordance with wholesale and retail prices. In continuation of the research, the aim of the work was to study and implement innovative approaches in the pharmacotherapy of systemic autoimmune diseases by content analysis on the example of antiviral drugs for international nonproprietary name (INN) Acyclovir. Materials and methods. The information base of the study consisted of scientific works of foreign and domestic scientists on the topic of the article. The review of scientific sources of literature was carried out taking into account the recommendations of the Cochrane Society for PICO. The names of drugs were systematized by INN, trade names, the number of drugs, dosage forms. For the content analysis, the method of drug selection developed by the Department of Medical and Pharmaceutical Law, General and Clinical Pharmacy of the Kharkiv Medical Academy of Postgraduate Education was used, which included seven criteria. Discussion. At the first stage of the study, a marketing analysis of the range of drugs for INN Acyclovir was performed. Medicines were selected, which according to the State Register of Medicines of Ukraine as of November 2020 were registered and allowed for circulation in health care facilities. After summarizing the processed data, a marketing list of drugs was compiled under the ATC code J05AB01 in accordance with the INN Acyclovir, which has 36 names of drugs. During the study, a discrete variation series of drug distribution was compiled, which indicates that the studied quantitative indicator of drug manufacturers fluctuates within the first group with the highest frequency (fi = 8). A graphic discrete variation in the form of a distribution polygon was created. Conclusions. Innovative approaches to the pharmacotherapy of systemic autoimmune diseases are the use of content analysis as an additional method in the study of pharmacotherapy of drugs. The study is based on the formalized method of qualitative and quantitative analysis of documents, which allows you to get a detailed picture of the selected clinical and pharmacological group of drugs – drugs by INN Aciclovir PBX code J05AB01. The analysis allows obtaining a complete description of the range and manufacturers of drugs approved for use.