Affiliation:
1. Süleyman Demirel Üniversitesi Tıp Fakültesi Radyoloji Anabilim Dalı
2. SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ
Abstract
Objective
Shear wave elastography (SWE) is a new
ultrasonography technique that can non-invasively
evaluate liver stiffness. The efficacy of SWE in adults
has been demonstrated by numerous studies, but
there are few SWE studies of pediatric groups. Since
the liver stiffness values (LSV) vary according to the
device and the SWE method used, standard reference
values have not been established as yet. The aim of
this study was to establish the reference values of
normal liver stiffness in healthy children according to
the two SWE methods.
Materials and Method
Liver stiffness values were measured using the two
different SWE methods of point SWE (pSWE) and
2-dimensional SWE (2D-SWE) in 107 healthy children
aged 8-18 years with no liver disease. The pSWE
(EPQ) and 2D-SWE (EQI) measurements were taken
in one session on the same device (Philips Epiq Elite)
and after at least 4 hours of fasting. The effects on
liver elasticity values were investigated of gender,
age, body mass index (BMI), some biochemical
markers (such as fasting blood glucose, aspartate
aminotransferase (AST), alanine aminotransferase
(ALT), albumin, platelet, INR) and liver size.
Results
The mean LSV was 4.04±0.84kPa ((95% confidence
interval (CI):3.67-4.42)) on pSWE and 4.41±0.71kPa
(95% CI:4.09-4.72) on 2D-SWE. The upper limit LSVs
were found to be 4.42kPa and 4.72kPa, respectively.
The LSVs measured on 2D-SWE were found to be
higher than on pSWE ((median; min-max, 4.34kPa;
2.82-6kPa and 3.86kPa; 2.55–5.78, respectively,
(r=0.59, p
Publisher
Medical Journal of Suleyman Demirel University