Targeting the pregnane X receptor using microbial metabolite mimicry

Author:

Dvořák Zdeněk1ORCID,Kopp Felix2,Costello Cait M3,Kemp Jazmin S3,Li Hao4,Vrzalová Aneta1,Štěpánková Martina1,Bartoňková Iveta1,Jiskrová Eva1,Poulíková Karolína1,Vyhlídalová Barbora1,Nordstroem Lars U2,Karunaratne Chamini V2,Ranhotra Harmit S4,Mun Kyu Shik5,Naren Anjaparavanda P5,Murray Iain A6,Perdew Gary H6,Brtko Julius7,Toporova Lucia7,Schön Arne8,Wallace Bret D9,Walton William G9,Redinbo Matthew R9,Sun Katherine10,Beck Amanda11,Kortagere Sandhya12ORCID,Neary Michelle C13,Chandran Aneesh14,Vishveshwara Saraswathi14,Cavalluzzi Maria M15,Lentini Giovanni15,Cui Julia Yue16,Gu Haiwei17,March John C3,Chatterjee Shirshendu18,Matson Adam19,Wright Dennis20,Flannigan Kyle L21,Hirota Simon A21,Sartor Ryan Balfour22,Mani Sridhar4ORCID

Affiliation:

1. Department of Cell Biology and Genetics Palacký University Olomouc Czech Republic

2. Department of Biochemistry Albert Einstein College of Medicine Bronx NY USA

3. The Department of Biological and Environmental Engineering Cornell University Ithaca NY USA

4. Department of Medicine, Genetics and Molecular Pharmacology Albert Einstein College of Medicine Bronx NY USA

5. Cincinnati Children's Hospital Medical Center Cincinnati OH USA

6. Department of Veterinary and Biomedical Sciences Penn State College of Agricultural Sciences University Park PA USA

7. Institute of Experimental Endocrinology Biomedical Research Center Slovak Academy of Sciences Bratislava Slovak Republic

8. The Department of Biology Johns Hopkins University Baltimore MD USA

9. Department of Chemistry University of North Carolina Chapel Hill NC USA

10. The Department of Pathology New York University School of Medicine New York NY USA

11. Department of Pathology Albert Einstein College of Medicine Bronx NY USA

12. Department of Microbiology and Immunology Drexel University College of Medicine Philadelphia PA USA

13. Department of Chemistry City University of New York‐Hunter College New York NY USA

14. Molecular Biophysics Unit Indian Institute of Science Bangalore India

15. Department of Pharmacy—Pharmaceutical Sciences University of Bari Aldo Moro Bari Italy

16. Department of Environmental and Occupational Health Sciences University of Washington Seattle WA USA

17. Center for Metabolic and Vascular Biology College of Health Solutions Arizona State University Scottsdale AZ USA

18. City University of New York City College and Graduate Center New York NY USA

19. Department of Pediatrics and Immunology University of Connecticut Farmington CT USA

20. Department of Pharmaceutical Sciences University of Connecticut Storrs CT USA

21. Department of Physiology and Pharmacology University of Calgary Calgary AB Canada

22. Division of Gastroenterology and Hepatology Department of Medicine Center for Gastrointestinal Biology and Disease University of North Carolina at Chapel Hill Chapel Hill NC USA

Funder

National Institute of Environmental Health Sciences

National Cancer Institute

Congressionally Directed Medical Research Programs

Crohn's and Colitis Foundation of America

Publisher

EMBO

Subject

Molecular Medicine

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