AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

Author:

Marino Marika12ORCID,Zhou Lujia12ORCID,Rincon Melvin Y12,Callaerts‐Vegh Zsuzsanna3ORCID,Verhaert Jens12,Wahis Jérôme12ORCID,Creemers Eline124,Yshii Lidia125ORCID,Wierda Keimpe124,Saito Takashi6ORCID,Marneffe Catherine12,Voytyuk Iryna12,Wouters Yessica12,Dewilde Maarten12,Duqué Sandra I12,Vincke Cécile7ORCID,Levites Yona8,Golde Todd E8ORCID,Saido Takaomi C9,Muyldermans Serge7,Liston Adrian1510ORCID,De Strooper Bart121112ORCID,Holt Matthew G121213ORCID

Affiliation:

1. VIB‐KU Leuven Center for Brain and Disease Research Leuven Belgium

2. Department of Neurosciences KU Leuven Leuven Belgium

3. Faculty of Psychology Laboratory of Biological Psychology KU Leuven Leuven Belgium

4. Electrophysiology Expertise Unit VIB‐KU Leuven Center for Brain and Disease Research Leuven Belgium

5. Department of Microbiology, Immunology and Transplantation KU Leuven Leuven Belgium

6. Department of Neurocognitive Science Institute of Brain Science Nagoya City University Graduate School of Medical Sciences Nagoya Japan

7. Laboratory of Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium

8. Department of Neuroscience Center for Translational Research in Neurodegenerative Disease McKnight Brain Institute College of Medicine University of Florida Gainesville FL USA

9. Laboratory for Proteolytic Neuroscience RIKEN Brain Science Institute Wako‐shi Japan

10. Immunology Programme The Babraham Institute Cambridge UK

11. UK Dementia Research institute at UCL London UK

12. Leuven Brain Institute Leuven Belgium

13. Instituto de Investigação e Inovação em Saúde (i3S) University of Porto Porto Portugal

Funder

Fonds Wetenschappelijk Onderzoek

Fondation Thierry Latran

European Research Council

Vlaams Instituut voor Biotechnologie

H2020 Spreading Excellence and Widening Participation

Publisher

EMBO

Subject

Molecular Medicine

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