Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis

Author:

Placek Katerina1ORCID,Benatar Michael2,Wuu Joanne2,Rampersaud Evadnie3,Hennessy Laura1,Van Deerlin Vivianna M4,Grossman Murray1,Irwin David J1,Elman Lauren1,McCluskey Leo1,Quinn Colin1,Granit Volkan2,Statland Jeffrey M5,Burns Ted M6,Ravits John7,Swenson Andrea8,Katz Jon9,Pioro Erik P10,Jackson Carlayne11,Caress James12,So Yuen13,Maiser Samuel14,Walk David14,Lee Edward B4,Trojanowski John Q4,Cook Philip15,Gee James15,Sha Jin1617,Naj Adam C41617,Rademakers Rosa18ORCID,Chen Wenan3,Wu Gang3,Paul Taylor J319,McMillan Corey T1ORCID,

Affiliation:

1. Department of Neurology University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

2. Department of Neurology Leonard M. Miller School of Medicine University of Miami Miami FL USA

3. Center for Applied Bioinformatics St. Jude Children’s Research Hospital Memphis TN USA

4. Department of Pathology & Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

5. Department of Neurology University of Kansas Medical Center Kansas City KS USA

6. Department of Neurology University of Virginia Health System Charlottesville VA USA

7. Department of Neurosciences University of California San Diego San Diego CA USA

8. Department of Neurology University of Iowa Iowa City IA USA

9. Forbes Norris ALS CenterCalifornia Pacific Medical Center San Francisco CA USA

10. Department of Neurology Cleveland Clinic Cleveland OH USA

11. Department of Neurology University of Texas Health Science Center San Antonio TX USA

12. Department of Neurology Wake Forest University School of Medicine Winston‐Salem NC USA

13. Department of Neurology Stanford University Medical Center San Jose CA USA

14. Department of Neurology University of Minnesota Medical Center Minneapolis MN USA

15. Penn Image Computing Science Laboratory (PICSL) Department of Radiology University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

16. Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

17. Penn Neurodegeneration Genomics Center Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

18. Department of Neuroscience Mayo Clinic Jacksonville FL USA

19. The Howard Hughes Medical InstituteChevy Chase MS USA

Funder

National Institutes of Health

Amyotrophic Lateral Sclerosis Association

Publisher

EMBO

Subject

Molecular Medicine

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