Aβ43‐producing PS 1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation-Reference-Cited by-同舟云学术

Aβ43‐producing PS 1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation

Published:2019-11-25 Issue:1 Volume:21 Page:
ISSN:1469-221X
Container-title:EMBO reports
language:en
Short-container-title:EMBO Rep

Author:

Trambauer Johannes¹^ORCID,Rodríguez Sarmiento Rosa María²,Fukumori Akio³⁴,Feederle Regina⁵⁶^ORCID,Baumann Karlheinz²,Steiner Harald¹⁶^ORCID

Affiliation:

1. Biomedical Center (BMC), Metabolic Biochemistry Ludwig‐Maximilians‐University Munich Germany

2. Roche Pharma Research and Early Development Roche Innovation Center Basel, F. Hoffmann‐La Roche Ltd. Basel Switzerland

3. Department of Aging Neurobiology National Center for Geriatrics and Gerontology Obu Japan

4. Department of Mental Health Promotion Osaka University Graduate School of Medicine Toyonaka Japan

5. Institute for Diabetes and Obesity, Monoclonal Antibody Core Facility, Helmholtz Center Munich German Research Center for Environmental Health Neuherberg Germany

6. German Center for Neurodegenerative Diseases (DZNE) Munich Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embr.201947996

Reference54 articles.

1. Neuropathological Alterations in Alzheimer Disease

2. Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase

3. -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of -Carboxyl Terminal Fragment

4. The amyloid hypothesis of Alzheimer's disease at 25 years

5. Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?

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