RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency-Reference-Cited by-同舟云学术

RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency

Published:2022-02-14 Issue:6 Volume:41 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Stok Jorn E¹^ORCID,Oosenbrug Timo¹^ORCID,Haar Laurens R¹^ORCID,Gravekamp Dennis¹^ORCID,Bromley Christian P²^ORCID,Zelenay Santiago²^ORCID,Reis e Sousa Caetano³^ORCID,Veen Annemarthe G¹^ORCID

Affiliation:

1. Department of Immunology Leiden University Medical Centre Leiden The Netherlands

2. Cancer Research UK Manchester Institute The University of Manchester Alderley Park UK

3. Immunobiology Laboratory The Francis Crick Institute London UK

Funder

Cancer Research UK

Medical Research Council

Manchester Biomedical Research Centre

Cancer Research UK Manchester Centre

Louis-Jeantet Foundation

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

H2020 European Research Council

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2021109760

Reference71 articles.

1. Regulation of cGAS- and RLR-mediated immunity to nucleic acids

2. Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

3. IRF-3-dependent and augmented target genes during viral infection

4. Purifying selection of long dsRNA is the first line of defense against false activation of innate immunity

5. ADAR1: A New Target for Immuno-oncology Therapy

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