Autophagy in major human diseases

Author:

Klionsky Daniel J1ORCID,Petroni Giulia2,Amaravadi Ravi K34,Baehrecke Eric H5,Ballabio Andrea678ORCID,Boya Patricia9ORCID,Bravo‐San Pedro José Manuel1011,Cadwell Ken121314,Cecconi Francesco151617ORCID,Choi Augustine M K1819,Choi Mary E1920,Chu Charleen T21ORCID,Codogno Patrice2223ORCID,Colombo Maria Isabel24,Cuervo Ana Maria2526ORCID,Deretic Vojo2728,Dikic Ivan2930ORCID,Elazar Zvulun31,Eskelinen Eeva‐Liisa32,Fimia Gian Maria3334ORCID,Gewirtz David A35ORCID,Green Douglas R36,Hansen Malene37,Jäättelä Marja3839ORCID,Johansen Terje40ORCID,Juhász Gábor4142,Karantza Vassiliki43,Kraft Claudine4445ORCID,Kroemer Guido4647484950ORCID,Ktistakis Nicholas T51,Kumar Sharad5253ORCID,Lopez‐Otin Carlos5455ORCID,Macleod Kay F5657,Madeo Frank585960,Martinez Jennifer61,Meléndez Alicia6263,Mizushima Noboru64ORCID,Münz Christian65ORCID,Penninger Josef M6667,Perera Rushika M686970ORCID,Piacentini Mauro7172ORCID,Reggiori Fulvio73ORCID,Rubinsztein David C7475,Ryan Kevin M7677,Sadoshima Junichi78,Santambrogio Laura27980,Scorrano Luca8182ORCID,Simon Hans‐Uwe838485,Simon Anna Katharina86,Simonsen Anne878889ORCID,Stolz Alexandra2930ORCID,Tavernarakis Nektarios9091ORCID,Tooze Sharon A92ORCID,Yoshimori Tamotsu939495ORCID,Yuan Junying9697,Yue Zhenyu98,Zhong Qing99ORCID,Galluzzi Lorenzo2798010023ORCID,Pietrocola Federico101ORCID

Affiliation:

1. Life Sciences Institute University of Michigan Ann Arbor MI USA

2. Department of Radiation Oncology Weill Cornell Medical College New York NY USA

3. Department of Medicine University of Pennsylvania Philadelphia PA USA

4. Abramson Cancer Center University of Pennsylvania Philadelphia PA USA

5. Department of Molecular, Cell and Cancer Biology University of Massachusetts Medical School Worcester MA USA

6. Telethon Institute of Genetics and Medicine Pozzuoli Italy

7. Department of Translational Medical Sciences Section of Pediatrics Federico II University Naples Italy

8. Department of Molecular and Human Genetics Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute Texas Children Hospital Houston TX USA

9. Margarita Salas Center for Biological Research Spanish National Research Council Madrid Spain

10. Faculty of Medicine Department Section of Physiology Complutense University of Madrid Madrid Spain

11. Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED) Madrid Spain

12. Kimmel Center for Biology and Medicine at the Skirball Institute New York University Grossman School of Medicine New York NY USA

13. Department of Microbiology New York University Grossman School of Medicine New York NY USA

14. Division of Gastroenterology and Hepatology Department of Medicine New York University Langone Health New York NY USA

15. Cell Stress and Survival Unit Center for Autophagy, Recycling and Disease (CARD) Danish Cancer Society Research Center Copenhagen Denmark

16. Department of Pediatric Onco‐Hematology and Cell and Gene Therapy IRCCS Bambino Gesù Children's Hospital Rome Italy

17. Department of Biology University of Rome ‘Tor Vergata’ Rome Italy

18. Division of Pulmonary and Critical Care Medicine Joan and Sanford I. Weill Department of Medicine Weill Cornell Medicine New York NY USA

19. New York‐Presbyterian Hospital Weill Cornell Medicine New York NY USA

20. Division of Nephrology and Hypertension Joan and Sanford I. Weill Department of Medicine Weill Cornell Medicine New York NY USA

21. Department of Pathology University of Pittsburgh School of Medicine Pittsburgh PA USA

22. Institut Necker‐Enfants Malades INSERM U1151‐CNRS UMR 8253 Paris France

23. Université de Paris Paris France

24. Laboratorio de Mecanismos Moleculares Implicados en el Tráfico Vesicular y la Autofagia‐Instituto de Histología y Embriología (IHEM)‐Universidad Nacional de Cuyo CONICET‐ Facultad de Ciencias Médicas Mendoza Argentina

25. Department of Developmental and Molecular Biology Albert Einstein College of Medicine Bronx NY USA

26. Institute for Aging Studies Albert Einstein College of Medicine Bronx NY USA

27. Autophagy Inflammation and Metabolism (AIM Center of Biomedical Research Excellence University of New Mexico Health Sciences Center Albuquerque NM USA

28. Department of Molecular Genetics and Microbiology University of New Mexico Health Sciences Center Albuquerque NM USA

29. Institute of Biochemistry II School of Medicine Goethe University Frankfurt, Frankfurt am Main Germany

30. Buchmann Institute for Molecular Life Sciences Goethe University Frankfurt, Frankfurt am Main Germany

31. Department of Biomolecular Sciences The Weizmann Institute of Science Rehovot Israel

32. Institute of Biomedicine University of Turku Turku Finland

33. Department of Molecular Medicine Sapienza University of Rome Rome Italy

34. Department of Epidemiology Preclinical Research, and Advanced Diagnostics National Institute for Infectious Diseases ‘L. Spallanzani’ IRCCS Rome Italy

35. Department of Pharmacology and Toxicology School of Medicine Virginia Commonwealth University Richmond VA USA

36. Department of Immunology St. Jude Children's Research Hospital Memphis TN USA

37. Sanford Burnham Prebys Medical Discovery Institute Program of Development Aging, and Regeneration La Jolla CA USA

38. Cell Death and Metabolism Center for Autophagy, Recycling & Disease Danish Cancer Society Research Center Copenhagen Denmark

39. Department of Cellular and Molecular Medicine Faculty of Health Sciences University of Copenhagen Copenhagen Denmark

40. Department of Medical Biology Molecular Cancer Research Group University of Tromsø—The Arctic University of Norway Tromsø Norway

41. Institute of Genetics Biological Research Center Szeged Hungary

42. Department of Anatomy, Cell and Developmental Biology Eötvös Loránd University Budapest Hungary

43. Merck & Co., Inc. Kenilworth NJ USA

44. Institute of Biochemistry and Molecular Biology ZBMZ Faculty of Medicine University of Freiburg Freiburg Germany

45. CIBSS ‐ Centre for Integrative Biological Signalling Studies University of Freiburg Freiburg Germany

46. Centre de Recherche des Cordeliers Equipe Labellisée par la Ligue Contre le Cancer Université de Paris Sorbonne Université Inserm U1138 Institut Universitaire de France Paris France

47. Metabolomics and Cell Biology Platforms Institut Gustave Roussy Villejuif France

48. Pôle de Biologie Hôpital Européen Georges Pompidou AP‐HP Paris France

49. Suzhou Institute for Systems Medicine Chinese Academy of Medical Sciences Suzhou China

50. Karolinska Institute Department of Women's and Children's Health Karolinska University Hospital Stockholm Sweden

51. Signalling Programme Babraham Institute Cambridge UK

52. Centre for Cancer Biology University of South Australia Adelaide SA Australia

53. Faculty of Health and Medical Sciences University of Adelaide Adelaide SA Australia

54. Departamento de Bioquímica y Biología Molecular Facultad de Medicina Instituto Universitario de Oncología del Principado de Asturias (IUOPA) Universidad de Oviedo Oviedo Spain

55. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid Spain

56. The Ben May Department for Cancer Research The Gordon Center for Integrative Sciences W‐338 The University of Chicago Chicago IL USA

57. The University of Chicago Chicago IL USA

58. Institute of Molecular Biosciences NAWI Graz University of Graz Graz Austria

59. BioTechMed‐Graz Graz Austria

60. Field of Excellence BioHealth – University of Graz Graz Austria

61. Immunity, Inflammation and Disease Laboratory National Institute of Environmental Health Sciences NIH Research Triangle Park NC USA

62. Biology Department, Queens College City University of New York Flushing NY USA

63. The Graduate Center Biology and Biochemistry PhD Programs of the City University of New York New York NY USA

64. Department of Biochemistry and Molecular Biology Graduate School of Medicine The University of Tokyo Tokyo Japan

65. Viral Immunobiology Institute of Experimental Immunology University of Zurich Zurich Switzerland

66. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) Vienna BioCenter (VBC) Vienna Austria

67. Department of Medical Genetics Life Sciences Institute University of British Columbia Vancouver BC Canada

68. Department of Anatomy University of California, San Francisco San Francisco CA USA

69. Department of Pathology University of California, San Francisco San Francisco CA USA

70. Helen Diller Family Comprehensive Cancer Center University of California, San Francisco San Francisco CA USA

71. Department of Biology University of Rome “Tor Vergata” Rome Italy

72. Laboratory of Molecular Medicine Institute of Cytology Russian Academy of Science Saint Petersburg Russia

73. Department of Biomedical Sciences of Cells & Systems Molecular Cell Biology Section University of Groningen University Medical Center Groningen Groningen The Netherlands

74. Department of Medical Genetics Cambridge Institute for Medical Research University of Cambridge Cambridge UK

75. UK Dementia Research Institute University of Cambridge Cambridge UK

76. Cancer Research UK Beatson Institute Glasgow UK

77. Institute of Cancer Sciences University of Glasgow Glasgow UK

78. Department of Cell Biology and Molecular Medicine Cardiovascular Research Institute Rutgers New Jersey Medical School Newark NJ USA

79. Sandra and Edward Meyer Cancer Center New York NY USA

80. Caryl and Israel Englander Institute for Precision Medicine New York NY USA

81. Istituto Veneto di Medicina Molecolare Padova Italy

82. Department of Biology University of Padova Padova Italy

83. Institute of Pharmacology University of Bern Bern Switzerland

84. Department of Clinical Immunology and Allergology Sechenov University Moscow Russia

85. Laboratory of Molecular Immunology Institute of Fundamental Medicine and Biology Kazan Federal University Kazan Russia

86. The Kennedy Institute of Rheumatology NDORMS University of Oxford Oxford UK

87. Department of Molecular Medicine Institute of Basic Medical Sciences University of Oslo Oslo Norway

88. Centre for Cancer Cell Reprogramming Institute of Clinical Medicine University of Oslo Oslo Norway

89. Department of Molecular Cell Biology Institute for Cancer Research Oslo University Hospital Montebello Oslo Norway

90. Institute of Molecular Biology and Biotechnology Foundation for Research and Technology‐Hellas Heraklion, Crete Greece

91. Department of Basic Sciences School of Medicine University of Crete Heraklion, Crete Greece

92. Molecular Cell Biology of Autophagy The Francis Crick Institute London UK

93. Department of Genetics Graduate School of Medicine Osaka University Suita Japan

94. Department of Intracellular Membrane Dynamics Graduate School of Frontier Biosciences Osaka University Suita Japan

95. Integrated Frontier Research for Medical Science Division Institute for Open and Transdisciplinary Research Initiatives (OTRI) Osaka University Suita Japan

96. Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China

97. Department of Cell Biology Harvard Medical School Boston MA USA

98. Department of Neurology Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA

99. Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education Department of Pathophysiology Shanghai Jiao Tong University School of Medicine (SJTU‐SM) Shanghai China

100. Department of Dermatology Yale School of Medicine New Haven CT USA

101. Department of Biosciences and Nutrition Karolinska Institute Huddinge Sweden

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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