Serological Survey of Hantavirus in Inhabitants from Tropical and Subtropical Areas of Brazil-Reference-Cited by-同舟云学术

Serological Survey of Hantavirus in Inhabitants from Tropical and Subtropical Areas of Brazil

Published:2016 Issue: Volume:2016 Page:1-6
ISSN:1687-8639
Container-title:Advances in Virology
language:en
Short-container-title:Advances in Virology

Author:

Alves Morais Felipe¹²^ORCID,Pereira Alexandre³,Santo Pietro Pereira Aparecida³⁴,Lazaro Moreli Marcos⁵,Marcelo Aranha Camargo Luís⁶⁷,Schiavo Nardi Marcello⁸⁹,Farah Tófoli Cristina⁸,Araujo Jansen¹,Mara Dutra Lilia¹,Lopes Ometto Tatiana¹,Hurtado Renata¹,Carmona de Jesus Maués Fábio¹,Zingano Hinke Tiene⁶,Jaber Mahmud Sati⁶,Correia Lima Monica¹⁰,Tadeu Moraes Figueiredo Luiz¹¹,Luiz Durigon Edison¹

Affiliation:

1. Laboratório de Virologia Clínica e Molecular, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil

2. Laboratório de Sinalização Molecular, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-000 São Paulo, SP, Brazil

3. Laboratório de Genética, Instituto Butantan, 05503-900 São Paulo, SP, Brazil

4. Laboratório de Virologia, Instituto Butantan, 05503-900 São Paulo, SP, Brazil

5. Laboratório de Virologia, Universidade Federal de Goiás, 75801-615 Jatai, GO, Brazil

6. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05389-970 São Paulo, SP, Brazil

7. São Lucas Medical School, Rua Alexandre Guimarães 1928, 76000-000 Porto Velho, RO, Brazil

8. Instituto de Pesquisa Ecológica (IPE), 12960-000 Nazaré Paulista, SP, Brazil

9. Divisão Técnica de Medicina Veterinária e Manejo da Fauna Silvestre (DEPAVE-/SVMA), 04030-000 Prefeitura de São Paulo, SP, Brazil

10. Departamento Municipal de Saúde, 11950-000 Prefeitura de Cajati, SP, Brazil

11. Centro de Pesquisa em Virologia da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil

Abstract

Brazil has reported more than 1,600 cases of hantavirus cardiopulmonary syndrome (HPS) since 1993, with a 39% rate of reported fatalities. Using a recombinant nucleocapsid protein ofAraraquaravirus, we performed ELISA to detect IgG antibodies against hantavirus in human sera. The aim of this study was to analyze hantavirus antibody levels in inhabitants from a tropical area (Amazon region) in Rondônia state and a subtropical (Atlantic Rain Forest) region in São Paulo state, Brazil. A total of 1,310 serum samples were obtained between 2003 and 2008 and tested by IgG-ELISA, and 82 samples (6.2%), of which 62 were from the tropical area (5.8%) and 20 from the subtropical area (8.3%), tested positive. Higher levels of hantavirus antibody were observed in inhabitants of the populous subtropical areas compared with those from the tropical areas in Brazil.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Hindawi Limited

Subject

Infectious Diseases,Virology

Link

http://downloads.hindawi.com/journals/av/2016/8628949.pdf

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