Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff's Base Derivatives

Author:

Sabry Nermien M.12,Flefel Eman M.3,Al-Omar Mohamed A.4,Amr Abd El-Galil E.25

Affiliation:

1. Chemistry Department, Girls College of Science, King Khalid University, Abha 9004, Saudi Arabia

2. Applied Organic Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt

3. Photochemistry Department, National Research Center, Dokki, Cairo 12622, Egypt

4. Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

5. Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Abstract

A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine(2a,b)and corresponding Schiff's bases(3a–j)were synthesized from 2,6-bis-(3-amino-2-methyl-4-oxo-9-substituted-3,4-dihydropyrido-[30,20 : 4,5]-thieno[3,2-d]pyrimidin-7-yl)pyridines(1a,b)as starting materials. The compounds1a,bwere reacted with 2,3,4,5-tetrachlorophthalic anhydride in glacial acetic acid to give the corresponding bis-imides(2a,b). But they are treated with aromatic aldehydes in refluxing ethanol to afford the Schiff’s base derivatives(3a–j). The antimicrobial screening showed that many of these newly synthesized compounds had good antimicrobial activities comparable to streptomycin and fusidic acid as positive controls. The detailed synthesis, spectroscopic data, and antimicrobial activities of the synthesized compounds were reported.

Publisher

Hindawi Limited

Subject

General Chemistry

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