Adalimumab: Another Medication Related to Osteonecrosis of the Jaws?

Author:

Cassoni Andrea1,Romeo Umberto1,Terenzi Valentina1,Della Monaca Marco1,Rajabtork Zadeh Oriana1,Raponi Ingrid1,Fadda Maria Teresa1,Polimeni Antonella1,Valentini Valentino1

Affiliation:

1. Odontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, Italy

Abstract

Objective.The acronym MRONJ has been created in order to identify “Medication-Related Osteonecrosis of the Jaw,” observed after the use of Bisphosphonates, RANK ligand inhibitor, and antiangiogenic medications. Only a case of osteonecrosis of the jaw in a Chron’s disease patient following a course of Bisphosphonate and Adalimumab therapy has been recently described, so that it has been supposed that also this medication could promote manifestation of osteonecrosis.Clinical Case. On August, 2014, a 63-year-old female with a history of idiopathic arthritis treated with medical treatment with Adalimumab from 2010 to 2013 presented referring pain in the right mandible.Results. This patient presented with nonexposed osteonecrosis of the jaw after placement, on September, 2010, of four titanium fixtures in the mandible.Conclusions. The authors suggest that the biologic therapy with an anti-TNF-αantibody might promote the manifestation of osteonecrosis and compromise oral healing capacity of the bone.

Publisher

Hindawi Limited

Subject

General Dentistry

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