Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study-Reference-Cited by-同舟云学术

Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study

Published:2022-01-17 Issue: Volume:2022 Page:1-10
ISSN:2210-7185
Container-title:Analytical Cellular Pathology
language:en
Short-container-title:Analytical Cellular Pathology

Author:

Ghorab Doaa Shams-Deen¹²,Helaly Ahmed Mohamed³⁴^ORCID,El Mahdi Hoda Saleh¹,Khatatbeh Moawiah²,Ibrahiem Afaf Taha¹

Affiliation:

1. Pathology Department, Faculty of Medicine Mansoura University, Egypt

2. Basic Department, Faculty of Medicine Yarmouk University, Jordan

3. Forensic and Clinical Toxicology Department, Mansoura University, Egypt

4. Clinical Department, Faculty of Medicine Yarmouk University, Jordan

Abstract

Diffuse large B cell lymphoma is the most common type of lymphoma in Egypt with an unfavorable prognosis. The tumor microenvironment is rich in immune response either T cells or macrophages. The current study is aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry of DLBCL activities with the prognosis of the tumor. The results showed no positive relation between T cell and macrophage reaction to the tumor prognosis suggesting that this reaction is part of the tumor process and not a defense mechanism from the surrounding stroma.

Publisher

Hindawi Limited

Subject

Cancer Research,Cell Biology,Molecular Medicine,General Medicine,Pathology and Forensic Medicine

Link

http://downloads.hindawi.com/journals/acp/2022/9993496.pdf

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