Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies

Author:

Hernández-Muñoz Rolando1,Olguín-Martínez Marisela1,Aguilar-Delfín Irma2,Sánchez-Sevilla Lourdes1,García-García Norberto1,Díaz-Muñoz Mauricio3ORCID

Affiliation:

1. Departamento de Biología Celular, Instituto de Fisiología Celular, UNAM, 04510 México DF, Mexico

2. Instituto Nacional de Medicina Genómica (INMEGEN), 14610 México DF, Mexico

3. Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus UNAM, 76230 Juriquilla QRO, Mexico

Abstract

There is an important set of cirrhotic and diabetic patients that present both diseases. However, information about metabolic and cellular blood markers that are altered, in conjunction or distinctively, in the 3 pathological conditions is scarce. The aim of this project was to evaluate several indicators of prooxidant reactions and the membrane composition of blood samples (serum and red blood cells (RBCs)) from patients clinically classified as diabetic (n=60), cirrhotic (n=70), and diabetic with liver cirrhosis (n=25) as compared to samples from a similar population of healthy individuals (n=60). The results showed that levels of TBARS, nitrites, cysteine, and conjugated dienes in the RBC of cirrhotic patients were significantly increased. However, the coincidence of diabetes and cirrhosis partially reduced the alterations promoted by the cirrhotic condition. The amount of total phospholipids and cholesterol was greatly enhanced in the patients with both pathologies (between 60 and 200% according to the type of phospholipid) but not in the patients with only one disease. Overall, the data indicate that the cooccurrence of diabetes and cirrhosis elicits a physiopathological equilibrium that is different from the alterations typical of each individual malady.

Funder

Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

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