Regression of Left Ventricular Hypertrophy in Patients Combined with Peritoneal Dialysis and Hemodialysis

Abstract

Background/Aims. Combined peritoneal dialysis and hemodialysis (PHD) are used in treating PD patients who underwent technique failure. This study aimed to research the cardiac structural and functional change in patients before and after PHD. Methods. This retrospective study enrolled 58 patients at The Second Affiliated Hospital of Soochow University who switched from PD to PHD. Clinical data and echocardiographic examination results were collected. Data from the two groups with a normal distribution were compared with the paired t-test. A $p$ value <0.05 (two-tailed) was considered statistically significant. Results. A total of 58 subjects were enrolled, including 46 males and 12 females, with a median age of 50.2 ± 11.1 (47–68) years. The mean duration of peritoneal dialysis was 67.2 ± 33.6 months. Before and after PHD, the ultrafiltration volume ( $p$  = 0.021) and hemoglobin ( $p$  = 0.001) were increased, while SBP ( $p$  = 0.002), DBP ( $p$  = 0.002), phosphorus ( $p$  < 0.001), and ESA dosage ( $p$  < 0.001) were decreased. Before and after combined dialysis (PHD), the incidence of LVH was 76.4% and 61.8%, respectively ( $p$  = 0.013), and LVMI decreased from 173.8 ± 86.2 g/m2 to 160.6 ± 78.5 g/m2 ( $p$  < 0.001). Conclusion. Compared with PD alone, the combination of PD and HD resulted in regression of LVH and reduced LVMI.