Granulomatous Pancreatitis in a Patient with Acute Manifested Insulin-Dependent Diabetes Mellitus

Author:

Mandys Václav1,Kheck Michal2,Anděl Michal3

Affiliation:

1. Department of Pathology, Third Faculty of Medicine, Charles University in Prague, 100 00 Prague 10, Czech Republic

2. Department of Pathology, Regional Hospital Jihlava, 586 33 Jihlava, Czech Republic

3. Second Department of Internal Medicine, Third Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic

Abstract

Isolated granulomatous noncaseating pancreatitis is a rare condition exceptionally described in human population. We demonstrate a case of the a 71-years-old female patient suffering from recent diabetes mellitus, generalized atherosclerosis and hypertension who died due to pulmonary embolism and terminal bronchopneumonia. Lipomatosis of pancreatic tissue was observed during the postmortem examination. Histological examination of pancreatic tissue discovered multiple small noncaseating epithelioid cell and giant cell granulomas, partly replacing the islets of Langerhans. To our knowledge, our case represents the first description of noninfectious granulomatous pancreatitis associated with acute manifested insulin-dependent diabetes mellitus.

Publisher

Hindawi Limited

Subject

General Medicine

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Multiple etiologies explain the association between sarcoidosis and diabetes mellitus;Expert Review of Respiratory Medicine;2022-01-31

2. Granulomatous Insulitis as a Cause of Acute-Onset Insulin-Dependent Diabetes Mellitus in a Patient With a Pancreatic Endocrine Carcinoma;International Journal of Surgical Pathology;2016-07-28

3. Pancreatic tuberculosis;Journal of Gastroenterology and Hepatology;2016-01-28

4. Non-neoplastic pancreatic lesions that may mimic malignancy;Seminars in Diagnostic Pathology;2016-01

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