Netrin Family: Role for Protein Isoforms in Cancer

Author:

Bruikman Caroline Suzanne1,Zhang Huayu2,Kemper Anneli Maite2,van Gils Janine Maria2ORCID

Affiliation:

1. Amsterdam UMC, University of Amsterdam, Department of Vascular Medicine, Location Meibergdreef, Amsterdam, Netherlands

2. Leiden University Medical Center, Department of Internal Medicine, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, Netherlands

Abstract

Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology. From the netrin genes various isoforms are translated and regulated by alternative splicing. We review here the diversity of isoforms of the netrin family members and their known and potential roles in cancer.

Funder

Netherlands Heart Foundation

Publisher

Hindawi Limited

Subject

Molecular Biology,Biochemistry

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