Ginsenoside Rg1 as a Potential Regulator of Hematopoietic Stem/Progenitor Cells

Author:

He Fang1ORCID,Yao Guanping2

Affiliation:

1. Key Laboratory of Cell Engineering in Guizhou Province, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China

2. Department of Reproductive Medicine Center, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China

Abstract

Ginsenoside Rg1 (Rg1), a purified, active component of the root or stem of ginseng, exerts positive effects on mesenchymal stem cells (MSCs). Many recent studies have found that hematopoietic stem cells (HSCs), which can develop into hematopoietic progenitor cells (HPCs) and mature blood cells, are another class of heterogeneous adult stem cells that can be regulated by Rg1. Rg1 can affect HSC proliferation and migration, regulate HSC/HPC differentiation, and alleviate HSC aging, and these findings potentially provide new strategies to improve the HSC homing rate in HSC transplantation and for the treatment of graft-versus-host disease (GVHD) or other HSC/HPC dysplasia-induced diseases. In this review, we used bioinformatics methods, molecular docking verification, and a literature review to systematically explore the possible molecular pharmacological activities of Rg1 through which it regulates HSCs/HPCs.

Funder

Traditional Chinese Medicine and Ethnic Medicine Science and Technology Research Project of Guizhou Province

Publisher

Hindawi Limited

Subject

Cell Biology,Molecular Biology

Reference77 articles.

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5. Immunomodulating Activity of Ginsenoside Rg1 from Panax Ginseng

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