Brilliant Blue Dyes in Daily Food: How Could Purinergic System Be Affected?

Author:

Ferreira Leonardo Gomes Braga1,Faria Robson Xavier2ORCID,Ferreira Natiele Carla da Silva3,Soares-Bezerra Rômulo José3

Affiliation:

1. Laboratory of Inflammation, Oswaldo Cruz Foundation, Av. Brazil, 4365 Rio de Janeiro, RJ, Brazil

2. Laboratory of Toxoplasmosis, Oswaldo Cruz Foundation, Av. Brazil, 4365 Rio de Janeiro, RJ, Brazil

3. Laboratory of Cellular Communication, Oswaldo Cruz Foundation, Av. Brazil, 4365 Rio de Janeiro, RJ, Brazil

Abstract

Dyes were first obtained from the extraction of plant sources in the Neolithic period to produce dyed clothes. At the beginning of the 19th century, synthetic dyes were produced to color clothes on a large scale. Other applications for synthetic dyes include the pharmaceutical and food industries, which are important interference factors in our lives and health. Herein, we analyzed the possible implications of some dyes that are already described as antagonists of purinergic receptors, including special Brilliant Blue G and its derivative FD&C Blue No. 1. Purinergic receptor family is widely expressed in the body and is critical to relate to much cellular homeostasis maintenance as well as inflammation and cell death. In this review, we discuss previous studies and show purinergic signaling as an important issue to be aware of in food additives development and their correlations with the physiological functions.

Funder

Fundação de Amparo à Pesquisa do Estado do Rio de Janeir

Publisher

Hindawi Limited

Subject

Food Science

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