Antimicrobial Activities Along With Spectrophotometric Assessment of Stability Constants of Copper (II) and Cobalt (II) With 1,2-Bis(2,5-dimethoxybenzylidene) Hydrazine

Author:

Fatima Rida12,Nadeem Sohail1ORCID,Javed Mohsin1,Iqbal Shahid3ORCID,Alsaab Hashem O.4,Awwad Nasser S.5,Ibrahium Hala A.67,Elkaeed Eslam B.8,Alzhrani Rami M.9,Alshehri Sameer9,Ali H. Elhosiny101112,Mohyuddin Ayesha1,Shaheen Nusrat2

Affiliation:

1. Department of Chemistry, School of Science, University of Management and Technology, Lahore, Pakistan

2. Institute of Chemistry, Gulab Devi Educational Complex, Ferozepur Road, Lahore, Pakistan

3. Department of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST), H-12, Islamabad 46000, Pakistan

4. Department of Pharmaceutics and Pharmaceutical Technology, Taif University, P.O.Box 11099, Taif 21944, Saudi Arabia

5. Chemistry Department, Faculty of Science, King Khalid University, P.O.Box 9004, Abha 61413, Saudi Arabia

6. Biology Department, Faculty of Science, King Khalid University, P.O.Box 9004, Abha 61413, Saudi Arabia

7. Department of Semi Pilot Plant, Nuclear Materials Authority, P.O.Box 530, El Maadi, New Cairo, Egypt

8. Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia

9. Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O.Box 11099, Taif 21944, Saudi Arabia

10. Advanced Functional Materials & Optoelectronic Laboratory (AFMOL), Department of Physics, Faculty of Science, King Khalid University, P.O.Box 9004, Abha, Saudi Arabia

11. Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha 61413, P.O.Box 9004, Saudi Arabia

12. Physics Department, Faculty of Science, Zagazig University, Zagazig, Egypt

Abstract

The stability constants of 1,2-bis(2,5-dimethoxybenzylidene) hydrazine (DMBH) were determined using the modified Job’s method with the addition of the UV-Vis approach using salts of copper (II) (chloride and acetate) and salts of cobalt (II) (chloride and nitrate). Copper (II) chloride with a ligand at 1L:2M (stoichiometric ratio) was discovered to have a higher stability constant log value (6.995) than other metal salts. The stability constant log value (5.811) for cobalt (II) nitrate at 1L:2M (stoichiometric ratio) was found to be less stable than the other stability constants evaluated. Antimicrobial properties of the ligand were tested against Entamoeba coli, Candida albicans, and Staphylococcus aureus. The ligand was found to be effective against these strains, with positive results.

Funder

King Khalid University

Publisher

Hindawi Limited

Subject

Analytical Chemistry

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