A Computational Approach towards the Development of Newer Anticancer Agents

Author:

Sheikh Javed I.1,Juneja H. D.1,Ingle V. N.1

Affiliation:

1. Organic Chemistry Research Laboratory, Department of Chemistry, RTM Nagpur University, Nagpur-440 033, India

Abstract

In silicomolecular docking analyses of the novel 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-aryl-propane-1, 3-diones were performed in the active sites of enzyme cytochrome P450 reductase to obtain new anticancer agents computationally. 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-(4"-methoxy-phenyl)-propane-1, 3-dione(3f)was found to have maximum affinity for the active sites of enzyme.

Publisher

Hindawi Limited

Subject

General Chemistry

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