Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment

Author:

Chouchane Habib1ORCID,Najjari Afef2,Cherif Hanene1ORCID,Neifar Mohamed1ORCID,Sghaier Haïtham13ORCID,Ouzari Hadda Imene2ORCID,Cherif Ameur1ORCID

Affiliation:

1. Univ. Manouba, ISBST, LR11-ES31 BVBGR, Biotechpole Sidi Thabet, 2020, Ariana, Tunisia

2. Université de Tunis El Manar, Faculté des Sciences de Tunis, LR03ES03 Laboratoire de Microbiologie et Biomolécules Actives, 2092 Tunis, Tunisia

3. Laboratory “Energy and Matter for Development of Nuclear Sciences” (LR16CNSTN02), National Center for Nuclear Sciences and Technology (CNSTN), Sidi Thabet Technopark, Sidi Thabet 2020, Tunisia

Abstract

This study explored the possible use of a microbial carboxymethylated sulfated heteroexopolysaccharide (CS-hEPS) as a potential anticancer agent. The investigation was carried out through antioxidant, antifatigue, and antiproliferative activities. Antioxidant potential including scavenging DPPH and hydroxyl radical activities and reducing power was evaluated. Antifatigue activity was determined by assessing the endurance of mice using the forced swimming test. Following 30 days of CS-hEPS oral treatment at different doses, biochemical parameters related to fatigue such as lactic dehydrogenase (LDH), serum urea nitrogen (SUN), and hepatic glycogen (HG) contents were measured. Antitumor activities were investigated against human cancer liver and myelogenous leukemia cells. Results showed that CS-hEPS possesses notable antioxidant, antifatigue, and antitumor effects. CS-hEPS significantly inhibited the proliferation of leukemia (86.6 ± 0.32%) and cancer liver (58.6 ± 0.43%) cells. CS-hEPS are promising natural antioxidant, antifatigue, and antitumor harmless adjuvant materials that could be applied in human cancer therapy.

Funder

Ministère de l’Enseignement Supérieur et de la Recherche Scientifique

Publisher

Hindawi Limited

Subject

General Chemistry

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