Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

Author:

Díaz-Guerrero Abigail M.1ORCID,Castillo-Miranda Claudia A.2,Castro-Guerrero Carlos F.3ORCID,Peraza-Vázquez Hernán1ORCID,Morales-Cepeda Ana B.2ORCID,Peña-Delgado Adrián F.45

Affiliation:

1. Instituto Politécnico Nacional, Centro de Investigación en Ciencia Aplicada y Tecnología Aplicada (CICATA) Unidad Altamira, Carretera Tampico-Puerto Industrial de Altamira, Km 14.5, Altamira C.P. 89600, Mexico

2. Tecnológico Nacional de México/Instituto Tecnológico de Ciudad Madero, Centro de Investigación en Petroquímica, Parque Industrial Tecnia, Altamira C.P. 89603, Mexico

3. CONACyT-Instituto Nacional de Electricidad y Energías Limpias, Departamento de Sistemas Mecánicos, Reforma 113, Cuernavaca C.P. 62490, Mexico

4. Universidad Politécnica de Altamira, Nuevo Libramiento Altamira KM 3, Altamira/C.P. 89602, Mexico

5. Universidad Tecnológica de Altamira, Boulevard de los Ríos Km. 3+100, Puerto Industrial Altamira, Altamira C.P. 89601, Mexico

Abstract

Hydrogels are commonly used as Drug Delivery Systems (DDS) as patches due to its ability to store drug molecules within their structures. The release can be activated under certain stimuli, such as temperature and pH. In this paper, the mathematical modelling of acetaminophen release in hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is reported. The HPC/PAAm gel was synthesized in proportions of 25/75 wt% and was characterized by FTIR, DSC, optical microscopy, SEM, and TGA, with and without acetaminophen. The release tests were performed for hypothermic, normal, and febrile human body conditions, at 35, 37, and 39°C, respectively, on two release media: water and phosphate buffer solution. In order to describe the release of acetaminophen in HPC/PAAm gel, a genetic programming algorithm was used to accomplish Multigene Symbolic Regression (MSR). Characterization results showed that the drug was crystallized on the surface of the HPC/PAAm gel. Release test results showed that several simultaneous processes occurred in the acetaminophen diffusion phenomenon. A unique mathematical model was obtained by MSR. This model was able to describe the release of acetaminophen in HPC/PAAm gel with high values of R2 and adjusted R2 and to simulate the drug release at times beyond the end of the experiment. High values of R2 and low values of Coefficient of Variation (CV), Root-Mean-Square Error (RMSE), and Mean Absolute Error (MAE) were obtained from the comparison between the simulated and the experimental data. This allows to conclude that the mathematical model is reliable to represent and simulate the acetaminophen release in HPC/PAAm gel at 35, 37, and 39°C.

Funder

Instituto Tecnológico de Ciudad Madero

Publisher

Hindawi Limited

Subject

Polymers and Plastics

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3