Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination

Author:

Ghanizadeh Gerayeli Farhad1,Hosseini Farnaz1,Bagheri Zohreh2,Savardashtaki Amir3,Shabaninejad Zahra45,Amani Ali Mohammad1,Najafipour Sohrab67ORCID

Affiliation:

1. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

2. Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3. Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

4. Department of Nanotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

5. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

6. Department of Microbiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

7. Non Communicable Diseases Research Center, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

Abstract

Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. It is a reverse transcriptase inhibitor. This type of drug stops the reproduction of DNA and decreases the amount of the virus in the patients’ blood. Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs. In this study, we synthesized AgNP-modified β-cyclodextrin (β-CD) using green synthesis for the sensitive and selective zidovudine (ZDV) determination. Characterization of nanoparticles was done using different methods including infrared (IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and also, X-ray diffraction (XRD) patterns. The AgNP λ-max peak was at approximately 405 nm. In the presence of ZDV, yellow solution was turned to red color, and surface plasmon absorption band was dramatically centered at 560 nm. ZDV was determined in the range of 50–500 μM, and the detection limit value was obtained as 42 μM. The sensor was used to determine ZDV in tablets with good recovery.

Funder

Shiraz University of Medical Sciences

Publisher

Hindawi Limited

Subject

Analytical Chemistry

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