Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease

Author:

Kim Min Joo1ORCID,Cho Sun Wook1ORCID,Choi Sumin2,Ju Dal Lae2,Park Do Joon13ORCID,Park Young Joo13ORCID

Affiliation:

1. Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea

2. Department of Food Service and Nutrition Care, Seoul National University Hospital, Seoul, Republic of Korea

3. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

Abstract

Objectives. Because thyroid hormone is an important determinant of body weight and basal metabolic rate, we investigated the changes in the basal metabolic rate and body composition sequentially after treatment for Graves’ disease. Methods. A prospective cohort study was performed with six women newly diagnosed with Graves’ disease. During a 52-week treatment of methimazole, body composition, resting respiratory expenditure (REE), and handgrip strength were measured consecutively. Results. After methimazole treatment, body weight was initially increased (0–8 weeks), subsequently plateaued (8–24 weeks), and gradually decreased in the later period (24–52 weeks) despite the decreased food intake. The measured REE was 40% higher than the predicted REE at baseline, and it gradually decreased after treatment. REE positively correlated with thyroid hormone levels, peripheral deiodinase activity, and thyroid’s secretory capacity. Body compositional analyses showed that the fat mass increased during an earlier period (4–12 weeks), while the lean mass increased significantly during the later period (26–52 weeks). Consistent with the lean mass changes, muscle strength also significantly increased during the later period. Conclusions. Treatment of Graves’ disease increased body weight and fat mass transiently with decreased REE. However, long-term compositional changes moved in a beneficial direction increasing lean mass and reinforcing muscle strength, following decreasing fat percentages.

Funder

Ministry of Health and Welfare, Republic of Korea

Publisher

Hindawi Limited

Subject

Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

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