Comparison of Lyophilized Glutaraldehyde-Preserved Bovine Pericardium with Different Vascular Prostheses for Use as Vocal Cords Implants: Experimental Study

Author:

Olmos-Zuñiga J. Raúl1,Jasso-Victoria Rogelio1,Gaxiola-Gaxiola Miguel2,Sotres-Vega Avelina1,Hernández-Jiménez Claudia1,Baltazares-Lipp Matilde1,Arredondo del Bosque Fernando3,Santillan-Doherty Patricio4

Affiliation:

1. Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico

2. Department of Morphology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico

3. Department of Otolaryngology-Head and Neck Surgery, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico

4. Medical Direction, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico

Abstract

This study compared the use of lyophilized glutaraldehyde-preserved bovine pericardium (LGPBP), polytetrafluoroethylene (PTFE), polyethylene terephthalate (PET), and Teflon felt (TF) as implants for vocal cords (VC) medialization and aimed to assess the endoscopic, macroscopic, and microscopic VC changes after medialization in a canine model. In 18 mongrel dogs, the right VC were medialized with LGPBP and the left were implanted as follows: Group I (n=6): LGPBP and PTFE; Group II (n=6): LGPBP and PET; Group III (n=6): LGPBP and TF. Surgical handling of the implants was compared. Three months after surgery, macroscopic and microscopic changes of VC and implants were evaluated. LGPBP offered the best surgical handling (p=0.005, Kruskal-Wallis). TF implants showed extrusion (p=0.005, Kruskal-Wallis) and severe inflammation. All VC formed fibrous capsules around the implants; the ones developed by LGPBP implants were thinner (p=0.001, ANOVA, Tukey). VC implanted with synthetic materials showed eosinophilic infiltration (p=0.01, Kruskal-Wallis). We concluded that the LGPBP could be used as an implant for VC medialization because it is biocompatible, easy to handle and remove during surgical procedures, and nonabsorbable or extrudable and produces an inflammatory reaction similar to PTFE and PET.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The life‐cycle and restoration of the human vocal fold;Laryngoscope Investigative Otolaryngology;2022-12-15

2. Designing and 3D Printed PLA Based Implant Used in Treatment for Unilateral Vocal Cord Paralysis;International Journal of 3D Printing Technologies and Digital Industry;2021-10-19

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3