Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report

Author:

Zavala-Cerna Maria Guadalupe1,Moran-Moguel Maria Cristina2,Cornejo-Toledo Jesus Alejandro2,Gonzalez-Montoya Norma Guadalupe3,Sanchez-Corona Jose2,Salazar-Paramo Mario4,Nava-Zavala Arnulfo Hernan156ORCID,Aguilar-Chavez Erika Anita7,Alcaraz-Lopez Miriam Fabiola8,Gonzalez-Sanchez Alicia Guadalupe3,Gonzalez-Lopez Laura9ORCID,Gamez-Nava Jorge Ivan10ORCID

Affiliation:

1. Programa Internacional, Facultad de Medicina, Universidad Autonoma de Guadalajara, 44100 Zapopan, JAL, Mexico

2. Division de Medicina Molecular del Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico

3. Programa de Becarios en Investigacion del Instituto Mexicano del Seguro Social, Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico

4. Division de Investigacion en Salud, UMAE, Hospital de Especialidades, CMNO, IMSS and Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico

5. Unidad de Investigacion en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional de Occidente del Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico

6. Servicio de Medicina Interna, Inmunologia y Reumatologia, Hospital General de Occidente, Secretaria de Salud Jalisco, 45170 Guadalajara, JAL, Mexico

7. Unidad de Medicina Familiar 2, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico

8. Departamento de Medicina Interna-Reumatologia, Hospital General de Zona 14, Instituto Mexicano del Seguro Social, 44860 Guadalajara, JAL, Mexico

9. Departamento de Medicina Interna-Reumatologia del Hospital General Regional No. 110, Instituto Mexicano del Seguro Social y Programa de Doctorado en Salud Publica, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico

10. Unidad de Investigación en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional de Occidente del Instituto Mexicano del Seguro Social y Programa de Doctorado en Salud Publica, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico

Abstract

Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pathway for coupling between osteoblasts and osteoclasts, since OPG is able to inhibit osteoclast differentiation and activation. We aim to evaluate the association between SNPs C950T (rs2073617), C209T (rs3134069), T245G (rs3134070) in theTNFRSF11B(OPG) gene, and osteoporosis in RA. We included 81 women with RA and 52 healthy subjects in a cross-sectional study, genotyped them, and measured bone mineral density (BMD) at the lumbar spine and the femoral neck. Mean age in RA was50±12with disease duration of12±8years. According to BMD results, 23 (33.3%) were normal and 46 (66.7%) had osteopenia/osteoporosis. We found a higher prevalence of C allele for C950T SNP in RA. Polymorphisms C209T and T245G did not reach statistical significance in allele distribution. Further studies including patients from other regions of Latin America with a multicenter design to increase the sample size are required to confirm our findings and elucidate if C950T SNP could be associated with osteoporosis in RA.

Funder

Instituto Mexicano del Seguro Social

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3