Affiliation:
1. Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 2520373, Japan
Abstract
There is now a considerable body of experimental evidence that Parkinson’s disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role ofα-synuclein and LRRK2 in the abnormal phosphorylation of tau. In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition ofα-synuclein- and LRRK2-associated tau phosphorylation by HSPs.
Funder
Ministry of Education, Culture, Sports, Science, and Technology
Subject
Psychiatry and Mental health,Clinical Neurology,Neuroscience (miscellaneous)
Cited by
11 articles.
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