PPARγand Its Role in Cardiovascular Diseases

Abstract

Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. The activators of PPARγare already widely used in the treatment of diabetes mellitus. The cardioprotective effect of PPARγactivation has been studied extensively over the years making them potential therapeutic targets in diseases associated with cardiovascular disorders. However, they are also associated with adverse cardiovascular events such as congestive heart failure and myocardial infarction. This review aims to discuss the role of PPARγin the various cardiovascular diseases and summarize the current knowledge on PPARγagonists from multiple clinical trials. Finally, we also review the new PPARγagonists under development as potential therapeutics with reduced or no adverse effects.