Synthesis and Docking Studies of the NovelN-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor-Reference-Cited by-同舟云学术

Synthesis and Docking Studies of the NovelN-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor

Published:2014 Issue: Volume:2014 Page:1-5
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Gallardo-Alfonzo Salvador¹,Ocampo-Néstor Ana Lilia¹,Contreras-Celedón Claudia¹,Chacón-García Luis¹

Affiliation:

1. Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, Mexico

Abstract

The synthesis of the novel 1-adamantyl-(N-meso-dipyrrolylmethylene)-carboxamide is described, providing a three-step, two-pot reaction. Docking studies with 11β-HSD1 revealed favorable binding interactions with the enzyme.

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2014/294246.pdf

Reference22 articles.

1. CONVERSION OF CORTISONE TO COMPOUND F

2. Purification and Characterization of the Corticosteroid 1lβ-Dehydrogenase Component of the Rat Liver 1lβ-Hydroxysteroid Dehydrogenase Complex*

3. Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

4. Characterization and Biological Significance of Corticosteroid 11?-Dehydrogenase, the Oxidizing Component of 11?-Hydroxysteroid Dehydrogenase

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Crystal structure, antioxidant evaluation, theoretical investigation: DFT, docking, and ADMET properties evaluation of 1-[(E)-2-(2-fluorophenyl) diazan-1-ylidene] naphthalen-2(1H)-one;Journal of Molecular Structure;2024-12

2. Molecular docking and pharmacophoric modelling of 1,5-disubstituted tetrazoles as inhibitors of two proteins present in cancer, the ABL and the mutated T315I kinase;In Silico Pharmacology;2020-11-22