Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer-Reference-Cited by-同舟云学术

Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer

Published:2009 Issue: Volume:2009 Page:1-6
ISSN:1687-8450
Container-title:Journal of Oncology
language:en
Short-container-title:Journal of Oncology

Author:

Loong Herbert H.¹,Ma Brigette B.¹²,Chan Anthony T. C.¹²

Affiliation:

1. Department of Clinical Oncology, Prince of Wales Hospital, Shatin, New Territories, Hong Kong

2. State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, New Territories, Hong Kong

Abstract

The approval of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in the treatment of metastatic colorectal cancer (CRC) has expanded the armamentarium against this disease. This paper will review the historical progress and recent clinical developments of anti-EGFR therapies in the treatment of metastatic CRC. Novel strategies of targeting the EGFR pathway to improve efficacy as well as ongoing research in identifying specific molecular predictors of response will be discussed.

Publisher

Hindawi Limited

Subject

Oncology

Link

http://downloads.hindawi.com/journals/jo/2009/967920.pdf

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5. ERBB receptors and cancer: the complexity of targeted inhibitors

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