Binder-Loaded Amorphous Nanometer Calcium Phosphate in Preventing Enamel Demineralization in Orthodontic Patients

Abstract

With the popularization of oral health knowledge, people have gradually realized the importance of orthodontic treatment in oral health, so the number of patients undergoing orthodontic treatment has increased significantly. To improve the effect of orthodontic treatment, this article mainly studied the application of adhesives loaded with amorphous nanocalcium phosphate in the prevention of enamel demineralization in orthodontic patients. In the experiment, we used spray-drying technology to synthesize NACP. The collected dry particles were dispersed with absolute ethanol, sonicated for 10 minutes, dropped on a 200 ordinary carbon support film, and then dried and observed with a transmission electron microscope (TEM). Prevention of enamel demineralization in orthodontic patients was by adhesive-loaded amorphous nanocalcium phosphate. In this experiment, the membrane dialysis method was used to release the drug-loaded nanoparticles. The MH-5 microhardness tester was used to randomly select 3 positions on the buccal area of the enamel surface to measure the microhardness. After measuring the microhardness of each point, take the average of the readings of the 3 positions. Before and after the experiment, the difference of the enamel surface microhardness before and after the experiment was statistically analyzed. Before the scanning electron microscope observation, to avoid contamination of the window area of the enamel surface, which will cause interference with the scanning electron microscope observation, we use acetone to remove the acid-resistant nail polish coated on the enamel surface. Clean the attachments on the surface of the teeth first, then fix, dehydrate, and dry. When the release time reaches 52 h, the cumulative release rates of Cur in pH 5.4 and pH 7.4 buffers are 85.84 and 64.68%, respectively. The results show that by adjusting the concentration of PAA, it is possible to configure a mineralized liquid that can not only use the fluidity of NACP to penetrate into the collagen fibers but also transform into HAP within a suitable time, to achieve the purpose of repairing demineralized dentin.