Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation-Reference-Cited by-同舟云学术

Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation

Published:2022-09-15 Issue: Volume:2022 Page:1-9
ISSN:2314-6141
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Bak Seon Gyeong¹,Lim Hyung-Jin¹,Won Yeong-Seon¹,Lee Soyoung¹,Cheong Sun Hee²,Lee Seong Jin³,Bae Eun Young⁴,Lee Seung Woong¹^ORCID,Lee Seung Jae¹^ORCID,Rho Mun-Chual¹

Affiliation:

1. Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea

2. Department of Marine Bio Food Science, Chonnam National University, Yeosu 59626, Republic of Korea

3. CHA MEDITECH Co., Ltd., 199 Techno 2-ro, Daejeon 34025, Republic of Korea

4. Elohim Co., Ltd, R&D Center, 199 Techno 2-ro, Daejeon 34025, Republic of Korea

Abstract

Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.

Funder

Ministry of Oceans and Fisheries

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2022/2475699.pdf

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