Long-Term Treatment with Aqueous Garlic and/or Tomato Suspensions Decreases Ehrlich Ascites Tumors

Author:

Bom Jenifer1,Gunutzmann Patrícia1,Hurtado Elizabeth C. Pérez1,Maragno-Correa Jussara M. R.2,Kleeb Silvia Regina3,Lallo Maria Anete1

Affiliation:

1. Environmental and Experimental Pathology Post-Graduation, Paulista University (UNIP), Rua José Maria Whitaker 290, 05622-001 São Paulo, SP, Brazil

2. Pharmacology Department, Federal University of São Paulo (UNIFESP), Rua Sena Madureira, 04021-001 São Paulo, SP, Brazil

3. Veterinary Medicine, University Metodista of São Paulo, Rua Alfeu Tavares 149, 09641-000 São Bernardo do Campo, SP, Brazil

Abstract

We evaluated the preventive and therapeutic effects of aqueous suspensions of garlic, tomato, and garlic + tomato in the development of experimental Ehrlich tumors in mice. The aqueous suspensions (2%) were administered over a short term for 30 days before tumor inoculation and 12 days afterward, and suspensions at 6% were administered for 180 days before inoculation and for 12 days afterward. The volume, number, and characteristics of the tumor cells and AgNOR counts were determined to compare the different treatments. Aqueous 6% suspensions of garlic, tomato, and garlic + tomato given over the long term significantly reduced tumor growth but when given over the short term, they did not alter tumor growth.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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