Huntington's Disease: An Immune Perspective-Reference-Cited by-同舟云学术

Huntington's Disease: An Immune Perspective

Published:2011 Issue: Volume:2011 Page:1-7
ISSN:2090-1852
Container-title:Neurology Research International
language:en
Short-container-title:Neurology Research International

Author:

Nayak Annapurna¹²,Ansar Rafia¹,Verma Sunil K.³,Bonifati Domenico Marco⁴,Kishore Uday¹

Affiliation:

1. Centre for Infection, Immunity and Disease Mechanisms, Biosciences School of Health Sciences and Social Care, Brunel University, West London UB8 3PH, UK

2. Centre of Biotechnology and Bioinformatics, School of Life Sciences, Jawaharlal Nehru Institute for Advanced Study, Secunderabad, Andhra Pradesh, India

3. Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India

4. Unit of Neurology, Department of Neurological Disorders, Santa Chiara Hospital, Largo Medaglie d'oro 1, 38100 Trento, Italy

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.

Publisher

Hindawi Limited

Subject

Neurology (clinical),Neurology

Link

http://downloads.hindawi.com/journals/nri/2011/563784.pdf

Reference46 articles.

1. Huntington's disease

2. N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

3. Wild-Type Huntingtin Plays a Role in Brain Development and Neuronal Survival

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