Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs

Author:

Xu Wei12ORCID,Ling Peixue13,Zhang Tianmin3

Affiliation:

1. School of Pharmaceutical Science, Shandong University, Jinan 250012, China

2. Department of Pharmacy, Shandong Provincial Qian Foshan Hospital, Jinan 250014, China

3. Institute of Biopharmaceuticals of Shandong Province, Jinan 250101, China

Abstract

Oral administration is the most commonly used and readily accepted form of drug delivery; however, it is find that many drugs are difficult to attain enough bioavailability when administered via this route. Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh environment of the GI tract, (2) release of the drug in a controlled manner at target sites, (3) prolongation of the residence time in the gut by mucoadhesion, and (4) inhibition of efflux pumps to improve the drug accumulation. To explain the mechanisms for enhancement of oral bioavailability, we discussed the special stability of PMs, the controlled release properties of pH-sensitive PMs, the prolongation of residence time with mucoadhesive PMs, and the P-gp inhibitors commonly used in PMs, respectively. The primary purpose of this paper is to illustrate the potential of PMs for delivery of poorly water-soluble drugs with bioavailability being well maintained.

Publisher

Hindawi Limited

Subject

Automotive Engineering

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