Author:
Martin Klabusay,Viera Kohutova,Petr Coupek,Marie Nenickova,Eva Tesarova
Abstract
Background. The cytokine network remarkably influences homeostasis. There is not a complex analysis describing physiological values of soluble cytokines in healthy individuals.Methods. Authors used the ELISA method to detect soluble cytokines and costimulatory molecules simultaneously in the plasma of 30 blood donors.Results. Data are shown as (a range of concentrations; median) IL-2 (0–74.48 pg/mL; 0), IL-4 (0–65.18 pg/mL; 0), IL-5 (0–86.69 pg/mL; 0), IL-6 (0–73.17 pg/mL; 0), IL-8 (0–74.8 pg/mL; 0), IL-10 (0–12.6 pg/mL; 0), IL-13 (0–3.9 pg/mL; 0), sCD40L (0–3.5 ng/mL; 0), and TNF-α(0–67.6; 0). For the IL-6 receptor, the concentration was75.89±35.83ng/mL (average±SD), sCD2328.9±15.22ng/mL, and TGFβ114.98±12.39ng/mL. A special approach was taken for the analysis of values, which had median 0. A model for the probability of detectable level's occurrence for each interleukin was formulated with intervals of confidence.Conclusion. These results provide reference values for cytokine levels in the plasma of healthy individuals.
Funder
Interní grantová agentura Ministerstva zdravotnictví
Cited by
26 articles.
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