Engineering Microbial Cells for the Biosynthesis of Natural Compounds of Pharmaceutical Significance

Author:

Jeandet Philippe1ORCID,Vasserot Yann1,Chastang Thomas2,Courot Eric2

Affiliation:

1. Laboratory of Enology and Applied Chemistry, Research Unit on Vines and Wines in Champagne, UPRES EA 4707, Faculty of Sciences, University of Reims, P.O. Box 1039, 51687 Reims Cedex 02, France

2. Laboratory of Stress, Defenses, and Plant Reproduction, Research Unit on Vines and Wines in Champagne, UPRES EA 4707, Faculty of Sciences, University of Reims, P.O. Box 1039, 51687 Reims Cedex 02, France

Abstract

Microbes constitute important platforms for the biosynthesis of numerous molecules of pharmaceutical interest such as antitumor, anticancer, antiviral, antihypertensive, antiparasitic, antioxidant, immunological agents, and antibiotics as well as hormones, belonging to various chemical families, for instance, terpenoids, alkaloids, polyphenols, polyketides, amines, and proteins. Engineering microbial factories offers rich opportunities for the production of natural products that are too complex for cost-effective chemical synthesis and whose extraction from their originating plants needs the use of many solvents. Recent progresses that have been made since the millennium beginning with metabolic engineering of microorganisms for the biosynthesis of natural products of pharmaceutical significance will be reviewed.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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