Clinical Response and Transfusion Reactions of Sheep Subjected to Single Homologous Blood Transfusion

Author:

Sousa Rejane Santos1,Minervino Antonio Humberto Hamad2,Araújo Carolina Akiko Sato Cabral1,Rodrigues Frederico Augusto Mazzocca Lopes1,Oliveira Francisco Leonardo Costa1,Mori Clara Satsuki1ORCID,Zaminhan Janaina Larissa Rodrigues1,Moreira Thiago Rocha1,Sousa Isadora Karolina Freitas1,Ortolani Enrico Lippi1,Barrêto Júnior Raimundo Alves3

Affiliation:

1. Department of Clinical Science, Faculty of Veterinary Medicine, University of Sao Paulo, Avenida Professor Orlando Marques de Paiva, 87 Cidade Universitária, 05508-270 São Paulo, SP, Brazil

2. Institute of Biodiversity and Forest, Federal University of Western Pará, Avenida Vera Paz S/N, Salé, 68000-000 Santarém, PA, Brazil

3. Department of Animal Science, Federal Rural University of the Semiarid Region, Avenida Francisco Mota, s/n Bairro Presidente Costa e Silva, 59625-900 Mossoró, RN, Brazil

Abstract

Studies in relation to blood conservation and responses to transfusion are scarce for ruminants. We evaluated the clinical manifestations of sheep that received a single homologous transfusion of whole blood, focusing on transfusion reactions. Eighteen adult sheep were subjected to a single phlebotomy to withdraw 40% of the total blood volume, which was placed into CPDA-1 bags and then divided into G0, animals that received fresh blood, and G15 and G35, animals that received blood stored for 15 or 35 days, respectively. Clinical observations were recorded throughout the transfusion, whereas heart rate, respiratory rate, and rectal temperature were assessed at the following times: 24 hours after phlebotomy and before transfusion; 30 minutes, six, twelve, 24, 48, 72, and 96 hours and eight and 16 days after transfusion. All groups presented transfusion reactions, among which hyperthermia was the most frequent (50% of animals). Tachycardia occurred most frequently in the G35 animals (50% of them). During transfusion G35 animals presented more clinical manifestation(P<0.05). Transfusion of fresh or stored total blood improved the blood volume, but transfusion reactions occurred, demonstrating that a single transfusion of fresh or stored blood can cause inflammatory and febrile nonhemolytic transfusion reactions in sheep.

Publisher

Hindawi Limited

Subject

General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine

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