Correlation between Insulin Resistance and Microalbuminuria Creatinine Ratio in Postmenopausal Women

Abstract

Objective. To study the relationship between insulin resistance and urinary microalbumin creatinine ratio in postmenopausal women. Methods. The selected research group comprised 104 postmenopausal women with type 2 diabetes who were admitted to the Department of Endocrinology in the green card center at the First Affiliated Hospital of Hainan Medical University between 2017 and 2019 inclusive. Ninety-eight postmenopausal women with the normal blood glucose metabolism hospitalized in the same period were used as the control group. The age, body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, fasting blood glucose, fasting insulin (FINS), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and urinary albumin-creatinine ratio (UACR) were analyzed. The insulin resistance index (HOMR-IR) was calculated, and the correlation between IR and UACR was analyzed. Results. Levels of HOMA-IR, SBP, HbA1c, HDL-C, LDL-C, TC, TG, FPG, FINS, and UACR in the study group were higher than those in the control group, and a significant difference was found between the groups ( $P<0.05$ ). The level of DBP in the study group was lower than that in the control group, and the difference was statistically significant ( $P<0.05$ ). Pearson correlation analysis showed that UACR was positively correlated with HOMA-IR and HbA1c (r = 0.254, r = 0.565, $P<0.01$ ). Multiple linear stepwise regression analysis further showed that HOMA-IR and age were positively correlated with UACR ( $P<0.05$ ). Conclusion. There is a correlation between IR and UACR in postmenopausal women. IR is an independent risk factor for UACR.