Analysis of Subclinical Thyroid Dysfunction and Metabolic Abnormality in 28568 Healthy People

Abstract

We analyzed the detection rates of metabolic syndrome (MetS) and subclinical thyroid dysfunction, including subclinical hyperthyroidism (SCHyper) and subclinical hypothyroidism (SCH), in healthy people, as well as their relationship. Clinical data were collected from 28,568 healthy individuals who underwent physical examinations. The detection rates of SCHyper, SCH, and MetS, as well as in different genders and ages, were analyzed. The detection rate of SCHyper and SCH in females was significantly higher than that in males ( $P$  < 0.001), but that of MetS in males was significantly higher than that in females ( $P$  < 0.001). In each age group, the detection rate of SCH in females was higher than that in males ( $P$  < 0.001). The detection rate of SCH was significantly different in different age groups ( $P$  < 0.001). The detection rates of hyperlipidemia ( $P$  < 0.001), obesity ( $P$  = 0.004), hypertension ( $P$  = 0.009), and hyperglycemia ( $P$  < 0.001) in the female SCH group were significantly higher than those in the normal group. The detection rates of hyperlipidemia ( $P$  = 0.006), obesity ( $P$  = 0.04), and hypertension ( $P$  = 0.04) in the male SCH group were higher than those in the normal group. The males with SCHyper were more prone to hyperlipidemia ( $P$  = 0.02) and obesity ( $P$  = 0.03). In addition, the female SCHyper group was not significantly different from the normal group ( $P$  > 0.05). Conclusively, the detection rate of SCHyper and SCH in females is higher than that in males, which increases with age. Attention should be paid to subclinical thyroid dysfunction in elderly people, especially females. Early individualized screening and early intervention should be carried out for people with abnormal metabolism.