Effects of Korean Red Ginseng and HAART onvifGene in 10 Long-Term Slow Progressors over 20 Years: High Frequency of Deletions and G-to-A Hypermutation

Abstract

To investigate if Korean red ginseng (KRG) affectsvifgene, we determinedvifgene over 20 years in 10 long-term slowly progressing patients (LTSP) who were treated with KRG alone and then KRG plus HAART. We also compared these data with those of 21 control patients who did not receive KRG. Control patient group harbored only one premature stop codon (PSC) (0.9%), whereas the 10 LTSP revealed 78 defective genes (18.1%) (P<0.001). The frequency of small in-frame deletions was found to be significantly higher in patients who received KRG alone (10.5%) than 0% in the pre-KRG or control patients (P<0.01). Regarding HAART,vifgenes containing PSCs were more frequently detected in patients receiving KRG plus HAART than patients receiving KRG alone or control patients (P<0.01). In conclusion, our current data suggest that the high frequency of deletions and PSC in thevifgene is associated with KRG intake and HAART, respectively.