Outcome of Endometrial Cancer Stage IIIA with Adnexa or Serosal Involvement Only

Author:

Jobsen Jan J.1,Naudin ten Cate Lambert2,Lybeert Marnix L. M.3,Scholten Astrid4,van der Steen-Banasik Elzbieta M.5,van der Palen Job67,Stenfert Kroese Marika C.8,Slot Annerie9,Schutter Eltjo M. J.10,Siesling Sabine11

Affiliation:

1. Department of Radiation Oncology, Medisch Spectrum Twente, Haaksbergerstraat 55, 7513 ER Enschede, The Netherlands

2. Laboratorium Pathologie Oost Nederland, 7512 ER Enschede, The Netherlands

3. Department of Radiation Oncology, Catharina Hospital, Eindhoven, The Netherlands

4. Department of Clinical Oncology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

5. Arnhem Radiotherapeutic Institute, Arnhem, The Netherlands

6. Department of Research Methodology, Measurement, and Data Analysis, Faculty of Behavioral Science, University of Twente, 7500 AE Enschede, The Netherlands

7. Department of Clinical Epidemiology, Medisch Spectrum Twente, 7513 ER Enschede, The Netherlands

8. Radiotherapy Institute Steden en Omstreken, Deventer, The Netherlands

9. Radiotherapy Institute Friesland, Leeuwarden, The Netherlands

10. Department of Obstetrics and Gynaecology, Medisch Spectrum Twente, 7513 ER Enschede, The Netherlands

11. Comprehensive Cancer Centre North East, Enschede/Groningen, The Netherlands

Abstract

Objective. The aim of this study is to look at possible differences in outcome between serosa and adnexal involvement stage IIIA endometrial carcinoma.Methods. 67 patients with stage IIIA endometrial carcinoma were included, 46 with adnexal involvement and 21 with serosa. A central histopathological review was performed.Results. The 7-year locoregional failure rate was (LRFR) 2.2% for adnexal involvement and 16.0% for involvement of the serosa (P=.0522). The 7-year distant metastasis-free survival was 72.7% for adnexal involvement and 58.7% for serosa (P=.3994). The 7-year disease-specific survival (DSS) was 71.8% for patients with adnexal involvement and 75.4% for patients with serosa.Conclusion. Endometrial carcinoma stage IIIA with involvement of the adnexa or serosa showed to have a comparable disease-specific survival. Locoregional control was worse for serosa involvement compared to adnexa.

Publisher

Hindawi Limited

Subject

Obstetrics and Gynecology

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