Ginseng-plus-Bai-Hu-Tang Combined with Western Medicine for the Treatment of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Abstract

Objective. Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by chronic hyperglycemia, which is also accompanied by changes in blood lipids and protein. According to research reports, Ginseng-plus-Bai-Hu-Tang (GBHT) has significant antihyperglycemic activity. Nevertheless, the evidence of effectiveness is not enough. In order to verify the effectiveness and safety of GBHT combined with conventional Western medicine (CWM) in the treatment of T2DM, we carried out this meta-analysis. Method. We collected 7 electronic databases from the inception to September 1, 2021; then, 12 studies were selected. The data analysis and methodological evaluation were conducted by the software RevMan 5.3.3 and Stata 12.0. Results. The meta-analysis revealed that when GBHT was adopted in combination with CWM, the effective rate (OR = 2.98, 95% CI = [2.01, 4.43], $P$  < 0.00001), the FBG (MD = −0.86, 95% CI = [−1.06, −0.65], $P$  < 0.00001), 2hBG (MD = −0.80, 95% CI = [−1.05, −0.55], $P$  < 0.00001), and HbA1c (MD = −0.64, 95% CI = [−0.98, −0.30], $P$  = 0.0002) of T2DM patients improved significantly compared with the control group. After GBHT combined with CWM treatment, HOME-RI (MD = −0.75, 95% CI = [−1.38, −0.12] $P$  = 0.02) of T2DM patients was superior to CWM alone. In comparison, the benefit from FINS (MD = −1.42, 95% CI = [−4.46, −1.62], $P$  = 0.36) was not apparent. In addition, none of the adverse events mentioned occurred, indicating that it is safe enough. Conclusion. GBHT combined with CWM is an effective and safe as adjunctive treatment for patients with T2DM. Nevertheless, due to the limitation of the quality of the included studies, additional high-quality researches are required to further confirm these results.